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KMID : 0365819710110020155
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Journal of Pusan Medical College
1971 Volume.11 No. 2 p.155 ~ p.165
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Effects of Diminished Portal Blood Flow on Storage Iron Metabolism in Rabbits
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Abstract
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iron study the regulatory mechanism of tissue storage ron in subjects with liver damage, the author investigated the effects of diminished portal blood flow on the metabolism of tissue storage iron. Rabbits were used in this study. The portal vein was strictured near the hilus of the liver to diminish the portal blood flow approximately to half of normal flow. The changes in storage iron concentration of many organs such as the liver, spleen, kidney and bone marrow were observed following stricture of portal vein in normal animals, and following intravenous iron administration or blood withdrawal from the jugular vein. The results thus obtained could be summarized as follows:
1.Following stricture of portal vein in normal rabbits, the storage iron concentration of the liver decreased, those of the spleen and kidney increased, and that of the bone marrow was not remarkable,
2. Following intravenous iron administration in the rabbits with strictured portal vein, the storage iron cocentration of the liver increased for a short time, but less than in normal rabbits, and then decreased below normal level, those of the spleen, renal cortex and bone marrow increased in the early period as in normal rabbits and then decreased faster than in normal rabbits, and that of the renal medulla increased in the early period, not in the late period as in normal rabbits.
3. Following blood withdrawal in the rabbits with strictured portal vein the storage iron concentrations of the liver, spleen and bone marrow decreased as in normal rabbits, but that of kindey increased as time passed. It was remarkable that following blood withdrawal the storage iron concentration of the liver and bone marrow in the rabbits with strictured porta vein decreased more than in normal rabbits.
On the basis of the above results, it was suggested that the disturbance in°storage iron metabolism following diminution of portal blood flow might result from the parenchymal damage of the liver.
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